Pesquisa | SciELO

RESUMO Objetivo: Inquérito nacional de cobertura vacinal aos 12 e 24 meses de idade foi realizado para investigar as quedas nas coberturas a partir de 2016. Métodos: Amostra de 37.836 nascidos vivos das coortes de 2017 e 2018 residentes nas capitais, Distrito Federal (DF) e 12 cidades com mais de 100 mil habitantes, acompanhados nos primeiros 24 meses por registros nas cadernetas de vacinação. Setores censitários foram estratificados segundo condições socioeconômicas, e o mesmo número de crianças foi incluído para cada estrato. Calcularem-se coberturas vacinais de cada vacina e coberturas completas aos 12 e 24 meses, doses aplicadas, válidas e oportunas. Fatores familiares, maternos e da criança associados à cobertura foram pesquisados. Os motivos para não vacinar analisados foram: contraindicações médicas, dificuldades de acesso, problemas no funcionamento do programa e hesitação vacinal. Resultados: Os resultados preliminares mostram que menos de 1% das crianças não foram vacinadas, as coberturas pelo esquema completo são menores que 75% em todas as capitais e no DF, as vacinas com mais de uma dose perdem cobertura progressivamente, há diferenças entre os estratos socioeconômicos, favoráveis aos estratos mais altos em algumas cidades e aos estratos mais baixos em outras. Conclusão: Houve realmente redução da cobertura vacinal em todas as capitais e no DF para as crianças nascidas em 2017 e 2018, denotando piora na execução do Programa Nacional de Imunizações durante os anos de 2017 a 2019. O inquérito realizado não mensurou os impactos da pandemia de COVID-19 que podem ter reduzido ainda mais as coberturas vacinais.

ABSTRACT Objective: The national vaccination coverage survey on full vaccination at 12 and 24 months of age was carried out to investigate drops in coverage as of 2016. Methods: A sample of 37,836 live births from the 2017 or 2018 cohorts living in capital cities, the Federal District, and 12 inner cities with 100 thousand inhabitants were followed for the first 24 months through vaccine record cards. Census tracts stratified according to socioeconomic levels had the same number of children included in each stratum. Coverage for each vaccine, full vaccination at 12 and 24 months and number of doses administered, valid and timely, were calculated. Family, maternal and child factors associated with coverage were surveyed. The reasons for not vaccinating analyzed were: medical contraindications, access difficulties, problems with the program, and vaccine hesitancy. Results: Preliminary results showed that less than 1% of children were not vaccinated, full coverage was less than 75% at all capitals and the Federal District, vaccines requiring more than one dose progressively lost coverage, and there were inequalities among socioeconomic strata, favorable to the highest level in some cities and to the lowest in others. Conclusion: There was an actual reduction in full vaccination in all capitals and the Federal District for children born in 2017 and 2018, showing a deteriorating implementation of the National Immunization Program from 2017 to 2019. The survey did not measure the impacts of the COVID-19 pandemic, which may have further reduced vaccination coverage.

https://doi.org/10.1590/1980-549720230031

National Vaccine Coverage Survey 2020: methods and operational aspects
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Barata, Rita Barradas

; França, Ana Paula

; Guibu, Ione Aquemi

; Vasconcellos, Maurício Teixeira Leite de

; Moraes, José Cássio de

; Teixeira, Maria da Gloria Lima Cruz

; Domingues, Carla Magda Alan

; Borges, Maria Fernanda de Souza Oliveira

; de Azevedo, Roberta Nogueira Calandrini

; de Oliveira, Consuelo Silva

; Oliveira, Andrea de Nazaré Marvão

; Canales, Ivy Thereza

; Nascimento, Valdir

; Queiroz, Rejane Christine de Souza

; Lima, Luísa Helena de Oliveira

; Ramos Jr, Alberto Novaes

; Barbosa, Jaqueline Caracas

; Mirabal, Isabelle Ribeiro Barbosa

; Meira, Meiruska

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria Denise de Castro

; Gurgel, Ricardo Queiroz

; de Carvalho, Martha Suely Itaparica

; Cesar, Tayñana

; Maciel, Ethel Leonor Noia

; da Gama, Silvana Granado Nogueira

; Luhm, Karin Regina

; Boing, Antônio Fernando

; Mengue, Sotero Serrate

; de Oliveira, Sandra Maria do Valle Leone

; Lima, Jaqueline Costa

; Teles, Sheila Araújo

; Caetano, Karlla Antonieta Amorim

; de Araújo, Wildo Navegantes

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230031

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1980-549720230031

Brazilian multicenter study on pegvisomant treatment in acromegaly
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Boguszewski, Cesar L.

; Huayllas, Martha Katherine P

; Vilar, Lucio

; Naves, Luciana Ansaneli

; Ribeiro-Oliveira Junior, Antonio

; Soares, Beatriz Santana

; Czepielewski, Mauro Antonio

; Abucham, Julio

; Correa-Silva, Silvia Regina

; Bronstein, Marcello Delano

; Jallad, Raquel Soares

; Duarte, Felipe Gaia

; Musolino, Nina Rosa

; Kasuki, Leandro

; Gadelha, Monica Roberto

Archives of Endocrinology and Metabolism

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Ago 2019, Volume 63 Nº 4 Páginas 328 - 336

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during treatment. Safety data were reviewed. Predictors of response were determined by comparing controlled versus uncontrolled patients. Results 109 patients [61 women; median age at diagnosis 34 years; 95.3% macroadenomas] from 10 Brazilian centers were studied. Previous treatment included surgery (89%), radiotherapy (34%), somatostatin receptor ligands (99%), and cabergoline (67%). Before PEGV, median levels of GH, IGF-I and IGF-I % of upper limit of normal were 4.3 µg/L, 613 ng/mL, and 209%, respectively. Pre-diabetes/diabetes was present in 48.6% and tumor remnant in 71% of patients. Initial dose was 10 mg/day in all except 4 cases, maximum dose was 30 mg/day, and median exposure time was 30.5 months. PEGV was used as monotherapy in 11% of cases. Normal IGF-I levels was obtained in 74.1% of patients. Glycemic control improved in 56.6% of patients with pre-diabetes/diabetes. Exposure time, pre-treatment GH and IGF-I levels were predictors of response. Tumor enlargement occurred in 6.5% and elevation of liver enzymes in 9.2%. PEGV was discontinued in 6 patients and 3 deaths unrelated to the drug were reported. Conclusions In a real-life scenario, PEGV is a highly effective and safe treatment for acromegaly patients not controlled with other therapies.

https://doi.org/10.20945/2359-3997000000159 822 downloads

Roll enriched with Nile tilapia meal: sensory, nutritional, technological and microbiological characteristics
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CHAMBÓ, Ana Paula Sartorio

; SOUZA, Maria Luiza Rodrigues de

; OLIVEIRA, Edna Regina Netto de

; MIKCHA, Jane Martha Graton

; MARQUES, Diego Rodrigues

; MAISTROVICZ, Fabiana Carla

; VISENTAINER, Jesuí Vergilio

; GOES, Elenice Souza dos Reis

Food Science and Technology

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Dez 2018, Volume 38 Nº 4 Páginas 726 - 732

Resumo: En | Texto: En | PDF: En

Abstract This study evaluated the chemical composition, fatty acid profile, technological quality, sensory profile and microbiological characteristics of rolls with inclusion of 0, 5, 10 and 15% meal prepared with tilapia carcasses. Moisture and carbohydrate content were linearly reduced (P < 0.05) with increasing inclusion of tilapia meal, but a linear increase (P < 0.0001) was observed in protein (9.91 to 14.30%) and ash (1.74 to 4.65%) content. Lipids and calorific value of the rolls were not affected (P > 0.05) by inclusion levels, but 15% tilapia meal resulted in greater amount of polyunsaturated fatty acids (4.63%) in relation to 0% inclusion (4.46%). There was a linear increase (P < 0.0001) in the firmness of the breads (3.65 to 13.17N) and a linear decrease (P < 0.001) in volume and specific volume. Sensory attributes showed a negative linear effect (P < 0.01), with acceptance rates ranging from 85.24% (0% inclusion) to 70.57% (15% inclusion). It can be concluded that the inclusion of 5 to 15% tilapia meal in roll is effective to increase the protein, mineral matter, polyunsaturated fatty acids and the firmness of the roll, in addition to reducing carbohydrates and volume. Considering the reduction in sensory acceptance, it is recommended to use up to 10% tilapia meal in rolls.

https://doi.org/10.1590/1678-457x.15317 766 downloads

We must overcome the fear of change
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Oliveira, Martha Regina de

Revista Brasileira de Geriatria e Gerontologia

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Ago 2017, Volume 20 Nº 4 Páginas 461 - 462

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1981-22562017020.170099 984 downloads

Detection of tuberculosis drug resistance: a comparison by Mycobacterium tuberculosis MLPA assay versus Genotype®MTBDRplus
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Santos, Paula Fernanda Gonçalves dos

; Costa, Elis Regina Dalla

; Ramalho, Daniela M

; Rossetti, Maria Lucia

; Barcellos, Regina Bones

; Nunes, Luciana de Souza

; Esteves, Leonardo Souza

; Rodenbusch, Rodrigo

; Anthony, Richard M

; Bergval, Indra

; Sengstake, Sarah

; Viveiros, Miguel

; Kritski, Afrânio

; Oliveira, Martha M

Memórias do Instituto Oswaldo Cruz

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Jun 2017, Volume 112 Nº 6 Páginas 396 - 403

Resumo: En | Texto: En | PDF: En

BACKGROUND To cope with the emergence of multidrug-resistant tuberculosis (MDR-TB), new molecular methods that can routinely be used to screen for a wide range of drug resistance related genetic markers in the Mycobacterium tuberculosis genome are urgently needed. OBJECTIVE To evaluate the performance of multiplex ligaton-dependent probe amplification (MLPA) against Genotype® MTBDRplus to detect resistance to isoniazid (INHr) and rifampicin (RIFr). METHOD 96 culture isolates characterised for identification, drug susceptibility testing (DST) and sequencing of rpoB, katG, and inhA genes were evaluated by the MLPA and Genotype®MTBDRplus assays. RESULTS With sequencing as a reference standard, sensitivity (SE) to detect INHr was 92.8% and 85.7%, and specificity (SP) was 100% and 97.5%, for MLPA and Genotype®MTBDRplus, respectively. In relation to RIFr, SE was 87.5% and 100%, and SP was 100% and 98.8%, respectively. Kappa value was identical between Genotype®MTBDRplus and MLPA compared with the standard DST and sequencing for detection of INHr [0.83 (0.75-0.91)] and RIFr [0.93 (0.88-0.98)]. CONCLUSION Compared to Genotype®MTBDRplus, MLPA showed similar sensitivity to detect INH and RIF resistance. The results obtained by the MLPA and Genotype®MTBDRplus assays indicate that both molecular tests can be used for the rapid detection of drug-resistant TB with high accuracy. MLPA has the added value of providing information on the circulating M. tuberculosis lineages.

https://doi.org/10.1590/0074-02760160376 1493 downloads

Performance of a molecular assay to detect Mycobacterium tuberculosis complex DNA in clinical specimens: multicenter study in Brazil
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Verza, Mirela

; Schmid, Karen Barros

; Barcellos, Regina Bones

; Linck, Natali

; Bello, Graziele Lima

; Scapin, Daniel

; Sperhacke, Rosa Dea

; Silva, Márcia Susana Nunes

; Wollheim, Claudia

; Rivero, Martha Gabriela Celle

; Kritski, Afrânio Lineu

; Rezende Jr, Leonides

; Oliveira, Martha Maria

; Costa, Elis Regina Dalla

; Rossetti, Maria Lucia Rosa

Memórias do Instituto Oswaldo Cruz

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Fev 2017, Volume 112 Nº 2 Páginas 94 - 99

Resumo: En | Texto: En | PDF: En

BACKGROUND In high tuberculosis (TB) burden countries, there are few data on the performance of new molecular commercialised assays developed locally. OBJECTIVE To evaluate the performance of a new molecular commercialised assay for TB diagnosis (Detect-TB) in three laboratories. METHODS A total of 302 sputum samples from an equal number of patients with presumptive diagnosis of pulmonary tuberculosis (PTB) were submitted for routine smear microscopy, culture, and Detect-TB assay at three different sites in Brazil (the cities of Caxias do Sul, São Paulo and Canoas). FINDINGS Seventy four (24.7%) TB cases were diagnosed (65 bacteriologically confirmed). When compared to smear microscopy/culture results, the overall sensitivity and specificity of Detect-TB assay was 84.6% (CI 95%; 73.7-91.6) and 93.1% (CI 95%; 89.1-95.8), respectively. When compared to bacteriological and clinical diagnostic criteria, the sensitivity and specificity of Detect-TB assay was 74.3% (CI 95%; 63.3-82.9) and 92.9% (CI 95%; 88.7-95.6), respectively. Among the three sites - Caxias do Sul, São Paulo and Canoas - the sensitivity and specificity were respectively 94.7% and 97.8%; 71.4% and 93.9%, 82.1% and 88.9%. MAIN CONCLUSIONS These findings suggest that the Detect-TB assay could be applied routinely in reference laboratories across different regions in Brazil.

https://doi.org/10.1590/0074-02760160196 1103 downloads

A mudança de modelo assistencial de cuidado ao idoso na Saúde Suplementar: identificação de seus pontos-chave e obstáculos para implementação
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Oliveira, Martha Regina de

; Veras, Renato Peixoto

; Cordeiro, Hesio de Albuquerque

; Pasinato, Maria Teresa

Physis: Revista de Saúde Coletiva

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Dez 2016, Volume 26 Nº 4 Páginas 1383 - 1394

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A partir de uma análise crítica sobre os atuais modelos de atenção à saúde para idosos, este artigo apresenta uma proposta de linha do cuidado para este segmento etário, tendo como foco a promoção e a prevenção da saúde, de modo a evitar a sobrecarga do sistema de saúde. Enfatiza-se o setor suplementar, pois como um quarto da população utiliza este sistema, uma discussão mais minuciosa se faz necessária. O conhecimento científico já identificou corretamente os fatores de risco para a população idosa, mas isso não basta. É prioritário utilizar esse conhecimento para efetuar a necessária transição do modelo assistencial clínico para o preventivo. Este precisa se configurar como um fluxo de ações de educação, promoção da saúde, prevenção de doenças evitáveis, postergação de moléstias, cuidado precoce e reabilitação de agravos. Não se nega a importância das instâncias pesadas (hospital, instituições de longa permanência, entre outras), mas estamos particularmente preocupados com uma abordagem contemporânea, que cuide de forma adequada o idoso e diminua custos. Se não for deste modo, o sistema se torna inviável.

Abstract From a critical analysis of current models of health care for the elderly, this article proposes a care line for this age group, focusing on the promotion and health prevention in order to avoid overloading the health system. It emphasizes the supplementary sector, since a quarter of the population uses this system, a more thorough discussion is needed. Scientific knowledge has correctly identified the risk factors for the elderly, but this is not enough. It is a priority to use this knowledge to make the necessary transition from the clinical care to preventive model. This needs to be configured as a stream of education initiatives, health promotion, prevention of preventable diseases, postponement of diseases, early care and rehabilitation of injuries. There is no denying the importance of heavy bodies (hospital, long-term care facilities, etc.), but we are particularly concerned about an approach that improves the quality of life and decrease costs. If not so, the system becomes impractical.

https://doi.org/10.1590/s0103-73312016000400016 610 downloads

A mudança de modelo assistencial de cuidado ao idoso na Saúde Suplementar: identificação de seus pontos-chave e obstáculos para implementação
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Oliveira, Martha Regina de

; Veras, Renato Peixoto

; Cordeiro, Hesio de Albuquerque

; Pasinato, Maria Teresa

Physis: Revista de Saúde Coletiva

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Out 2016, Volume 26 Nº 4 Páginas 1383 - 1394

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0103-73312016000400016 3632 downloads

10.

Cross-cultural adaptation of the CDC Worksite Health ScoreCard questionnaire into Portuguese
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Soárez, Patrícia Coelho de

; Ciconelli, Rozana Mesquita

; Pavin, Thiago

; Ogata, Alberto José Niituma

; Curci, Kátia Audi

; Oliveira, Martha Regina de

Revista da Associação Médica Brasileira

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Jun 2016, Volume 62 Nº 3 Páginas 236 - 242

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: apesar do avanço na implementação dos Programas de Promoção da Saúde nos locais de trabalho, não temos disponível no Brasil um questionário que avalie a abrangência das intervenções de promoção da saúde adotadas e seu embasamento científico. Este estudo teve o objetivo de traduzir para o português brasileiro e adaptar culturalmente o questionário CDC Worksite Health ScoreCard (HSC). Método: o HSC possui 100 questões agrupadas em doze domínios. Foram seguidas as etapas: tradução, reconciliação, retro-tradução, revisão pelo painel de especialistas, pré-teste e revisão final. A amostra de conveniência incluiu 27 indivíduos de operadoras de planos de saúde e empresas de diversos tamanhos, tipos e indústrias do Estado de São Paulo. Os dados foram analisados por meio da estatística descritiva. Resultados: a média de idade da amostra foi de 38 anos; a maioria dos indivíduos eram do sexo feminino (21 de 27) e eram os responsáveis pelos programas de promoção da saúde desses locais de trabalho. A maioria das questões ficou acima do nível mínimo de compreensão de 90%. Os indivíduos consideraram o questionário muito útil para determinar a abrangência dos programas de promoção da saúde existentes e apontar áreas que poderiam ser desenvolvidas. Conclusão: a versão em português brasileiro do questionário HSC poderá ser uma ferramenta válida e útil para medir o grau de implantação das intervenções de promoção da saúde baseadas em evidências em organizações de saúde locais.

SUMMARY Objective: Despite the progress in the implementation of health promotion programs in the workplace, there are no questionnaires in Brazil to assess the scope of health promotion interventions adopted and their scientific basis. This study aimed to translate into Brazilian Portuguese and culturally adapt the CDC Worksite Health ScoreCard (HSC) questionnaire. Method: The HSC has 100 questions grouped into twelve domains. The steps are as follows: translation, reconciliation, back-translation, review by expert panel, pretesting, and final revision. The convenience sample included 27 individuals from health insurance providers and companies of various sizes, types and industries in São Paulo. Data were analyzed using descriptive statistics. Results: The average age of the sample was 38 years, most of the subjects were female (21 of 27), and were responsible for programs to promote health in these workplaces. Most questions were above the minimum value of understanding set at 90%. The participants found the questionnaire very useful to determine the extent of existing health promotion programs and to pinpoint areas that could be developed. Conclusion: The Brazilian Portuguese version of the HSC questionnaire may be a valid measure and useful to assess the degree of implementation of health promotion interventions based on evidence in local health organizations.

https://doi.org/10.1590/1806-9282.62.03.236 1909 downloads

11.

Trends in risk factors chronic diseases, according of health insurance, Brazil, 2008-2013
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Malta, Deborah Carvalho

; Bernal, Regina Tomie Ivata

; Oliveira, Martha

Ciência & Saúde Coletiva

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Abr 2015, Volume 20 Nº 4 Páginas 1005 - 1016

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O objetivo deste artigo é comparar as tendências dos fatores de risco e proteção de DCNT na população com e sem planos de saúde. São analisadas tendências temporais do inquérito telefônico Vigitel, realizado anualmente junto à população adulta nas capitais. Foram realizadas análises de série temporal das variáveis referentes aos fatores de risco e proteção de DCNT, no período entre 2008 a 2013. Foram comparadas as variáveis segundo a posse de planos de saúde, utilizando-se modelo de regressão linear simples. Reduziu a prevalência do tabagismo na população com e sem planos de saúde, em 0,72% e 0,69% ao ano respectivamente. O consumo de frutas, legumes e verduras cresceu 0,8% e 0,72% ao ano respectivamente na população com e sem planos de saúde. A prática de atividade física no tempo livre aumentou 1,17% e 1,01% ao ano na população com e sem planos. O excesso de peso aumentou em 1,03% e 0,74% ao ano na população com planos e sem planos, enquanto que a obesidade aumentou 1,53% e 0,95% ao ano com e sem planos, respectivamente. A mamografia aumentou 2,4% na população sem planos de saúde. O monitoramento do Vigitel mostrou melhora nos indicadores na população com planos e sem planos de saúde.

This article aims to compare the trends for risk and protective factors for NCD in the population with and without health insurance. Analysis of temporal trends of the Vigitel phone survey, collected annually in adult population. Were used analyzed the temporal series of variables referent to risk and protective factors for NCD, from 2008 to 2013. Variables were compared according to the possession or not of health insurance using simple linear regression model. There was a reduction in the prevalence of smoking in the population with and without health insurance, in 0.72% and 0,69% per year respectively. The consumption of fruits and vegetables grew 0,8% and 0.72% per year respectively among the population with and without health insurance. Physical activity in leisure time increased 1.17% and 1.01% per year among population with and without health insurance. Excess weight increased in 1.03% and obesity in 0.74% p.y in the population with health insurance and 1.53% and 0.95% p.y without health insurance. Mammography increased 2.4% in the population without health insurance. Vigitel monitoring showed improvement in the indicators in the population with and without health insurance.

https://doi.org/10.1590/1413-81232015204.14712014 1252 downloads

12.

Trends in risk factors chronic diseases, according of health insurance, Brazil, 2008-2013
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Malta, Deborah Carvalho

; Bernal, Regina Tomie Ivata

; Oliveira, Martha

Ciência & Saúde Coletiva

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Abr 2015, Volume 20 Nº 4 Páginas 1005 - 1016

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232015204.14712014 3412 downloads

13.

In house reverse membrane hybridisation assay versus GenoType MTBDRplus and their performance to detect mutations in the genes rpoB, katG and inhA
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Ferreira Junior, Sergio Luiz Montego

; Costa, Elis Regina Dalla

; Santos, Paula Gonçalves dos

; Gomes, Harrison Magdinier

; Silva, Marcia Susana Nunes

; Esteves, Leonardo Souza

; Oliveira, Martha Maria

; Maschmann, Raquel de Abreu

; Kritski, Afrânio Lineu

; Suffys, Philip Noel

; Rossetti, Maria Lucia Rosa

Memórias do Instituto Oswaldo Cruz

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Jun 2014, Volume 109 Nº 3 Páginas 307 - 314

Resumo: En | Texto: En | PDF: En

Drug-resistant tuberculosis (TB) threatens global TB control and is a major public health concern in several countries. We therefore developed a multiplex assay (LINE-TB/MDR) that is able to identify the most frequent mutations related to rifampicin (RMP) and isoniazid (INH) resistance. The assay is based on multiplex polymerase chain reaction, membrane hybridisation and colorimetric detection targeting of rpoB and katG genes, as well as the inhA promoter, which are all known to carry specific mutations associated with multidrug-resistant TB (MDR-TB). The assay was validated on a reference panel of 108 M. tuberculosis isolates that were characterised by the proportion method and by DNA sequencing of the targets. When comparing the performance of LINE-TB/MDR with DNA sequencing, the sensitivity, specificity and agreement were 100%, 100% and 100%, respectively, for RMP and 77.6%, 90.6% and 88.9%, respectively, for INH. Using drug sensibility testing as a reference standard, the performance of LINE-TB/MDR regarding sensitivity, specificity and agreement was 100%, 100% and 100% (95%), respectively, for RMP and 77%, 100% and 88.7% (82.2-95.1), respectively, for INH. LINE-TB/MDR was compared with GenoType MTBDRplus for 65 isolates, resulting in an agreement of 93.6% (86.7-97.5) for RIF and 87.4% (84.3-96.2) for INH. LINE-TB/MDR warrants further clinical validation and may be an affordable alternative for MDR-TB diagnosis.

https://doi.org/10.1590/0074-0276130469 1524 downloads

14.

Ganho de peso excessivo na gestação é fator de risco para o excesso de peso em mulheres
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Nast, Martha

; Oliveira, Andressa de

; Rauber, Fernanda

; Vitolo, Márcia Regina

Revista Brasileira de Ginecologia e Obstetrícia

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Dez 2013, Volume 35 Nº 12 Páginas 536 - 540

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar a retenção de peso 12 meses após o parto e seus fatores associados entre mulheres que realizaram o pré-natal em Unidades de Saúde da cidade de Porto Alegre. MÉTODOS: Gestantes no terceiro trimestre gestacional foram identificadas em 20 Unidades de Saúde, e dados socioeconômicos, demográficos e antropométricos foram coletados. Seis e 12 meses após o parto, realizou-se visita domiciliar às mulheres participantes para obtenção das medidas antropométricas. O ganho de peso gestacional foi avaliado considerando-se o índice de massa corporal (IMC) pré-gestacional. A retenção de peso foi obtida pela subtração do peso pré-gestacional, e o peso aferido 6 e 12 meses após o parto. Para análise dos dados, utilizou-se o Teste de McNemar, a ANOVA com as comparações múltiplas de Bonferroni e a regressão linear múltipla. RESULTADOS: Das 715 gestantes entrevistadas, 545 foram avaliadas 12 meses após o parto. A prevalência de excesso de peso 12 meses após o parto foi superior comparado ao período pré-gestacional (52,9 versus 36,7%) e 30,7% das mulhere retiveram ≥10 kg. A retenção de peso 12 meses após o parto foi superior nas mulheres que apresentavam sobrepeso pré-gestacional (9,9±7,7 kg) em comparação àquelas eutróficas (7,6±6,2 kg). Maior IMC pré-gestacional, maior ganho de peso gestacional e ser adolescente foram associados com maior retenção de peso 12 meses após o parto (p<0,001). CONCLUSÃO: É necessária a adequada assistência pré-natal para minimizar os efeitos adversos do ganho de peso excessivo durante a gestação na saúde da mulher.

PURPOSE: To evaluate weight retention 12 months postpartum and factors associated among women who had received prenatal care at Health Care Centers in Porto Alegre, southern Brazil. METHODS: Pregnant women in the last trimester were identified at 20 Health Care Centers. Socioeconomic, demographic and anthropometrics data were obtained. Six and 12 months after delivery, the women received home visits for anthropometric measures. The gestational weight gain was defined by pre-pregnancy Body Mass Index (BMI). Weight retention was defined as the difference between pre-gestational weight and weight at postpartum. Data were analyzed using McNemar's Test, ANOVA with Bonferroni correction and multiple linear regression. RESULTS: Of the 715 pregnant women recruited, 545 were assessed 12 months after delivery. Women were more likely to be overweight 12 months postpartum compared to the pre-pregnancy period (52.9 versus 36.7%) and weight retention during the 12 months postpartum was more than 10 kg in 30.7% of the women. Weight retention in the postpartum period was higher among women who were overweight (9.9±7.7 kg) compared to those who were of normal weight during the pre-pregnancy period (7.6±6.2 kg). Pre-pregnancy BMI, gestational weight gain, and maternal age were associated with gestational weight retention 12 months postpartum (p<0.001). CONCLUSION: Adequate prenatal care is necessary to minimize the adverse effects of excessive weight gain during pregnancy on women's health.

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15.

Colorimetric microwell plate reverse-hybridization assay for Mycobacterium tuberculosis detection
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Michelon, Candice Tosi

; Rosso, Franciele

; Schmid, Karen Barros

; Sperhacke, Rosa Dea

; Oliveira, Martha Maria

; Kritski, Afrânio Lineu

; Rezende Jr, Leonides

; Costa, Elis Regina Dalla

; Ribeiro, Andrezza Woloski

; Verza, Mirela

; Cafrune, Patrícia Izquierdo

; Silva, Márcia Susana Nunes

; Kuhleis, Daniele

; Zaha, Arnaldo

; Rossetti, Maria Lucia Rosa

Memórias do Instituto Oswaldo Cruz

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Mar 2011, Volume 106 Nº 2 Páginas 194 - 199

Resumo: En | Texto: En | PDF: En

Direct smear examination using Ziehl-Neelsen staining for pulmonary tuberculosis (PTB) diagnosis is inexpensive and easy to use, but has the major limitation of low sensitivity. Rapid molecular methods are becoming more widely available in centralized laboratories, but they depend on timely reporting of results and strict quality assurance obtainable only from costly commercial kits available in high burden nations. This study describes a pre-commercial colorimetric method, Detect-TB, for detecting Mycobacterium tuberculosis DNA in which an oligonucleotide probe is fixed onto wells of microwell plates and hybridized with biotinylated polymerase chain reaction amplification products derived from clinical samples. The probe is capable of hybridising with the IS6110 insertion element and was used to specifically recognise the M. tuberculosis complex. When combined with an improved silica-based DNA extraction method, the sensitivity of the test was 50 colony-forming units of the M. tuberculosis reference strain H37Rv. The results that were in agreement with reference detection methods were observed in 95.2% (453/476) of samples included in the analysis. Sensitivity and specificity for 301 induced sputum samples and 175 spontaneous sputum samples were 85% and 98%, and 94% and 100%, respectively. This colorimetric method showed similar specificity to that described for commercially available kits and may provide an important contribution for PTB diagnosis.

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